Reduced reward anticipation in youth at high-risk for unipolar depression: a preliminary study.
Identifieur interne : 001723 ( Main/Exploration ); précédent : 001722; suivant : 001724Reduced reward anticipation in youth at high-risk for unipolar depression: a preliminary study.
Auteurs : Thomas M. Olino [États-Unis] ; Dana L. Mcmakin [États-Unis] ; Judith K. Morgan [États-Unis] ; Jennifer S. Silk [États-Unis] ; Boris Birmaher [États-Unis] ; David A. Axelson [États-Unis] ; Douglas E. Williamson [États-Unis] ; Ronald E. Dahl [États-Unis] ; Neal D. Ryan [États-Unis] ; Erika E. Forbes [États-Unis]Source :
- Developmental cognitive neuroscience [ 1878-9307 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- physiologie : Affect.
- physiopathologie : Corps strié, Trouble dépressif.
- psychologie : Trouble dépressif.
- Adolescent, Anticipation psychologique, Autorapport, Femelle, Humains, Imagerie par résonance magnétique, Mâle, Risque, Récompense.
English descriptors
- KwdEn :
- MESH :
- physiology : Affect.
- physiopathology : Corpus Striatum, Depressive Disorder.
- psychology : Depressive Disorder.
- Adolescent, Anticipation, Psychological, Female, Humans, Magnetic Resonance Imaging, Male, Reward, Risk, Self Report.
Abstract
Offspring of depressed parents are at risk for depression and recent evidence suggests that reduced positive affect (PA) may be a marker of risk. We investigated whether self-reports of PA and fMRI-measured striatal response to reward, a neural correlate of PA, are reduced in adolescent youth at high familial risk for depression (HR) relative to youth at low familial risk for depression (LR). Functional magnetic resonance imaging assessments were conducted with 14 HR and 12 LR youth. All youth completed an ecological momentary assessment protocol to measure PA in natural settings and a self-report measure of depression symptomatology. Analyses found that HR youth demonstrated lower striatal response than LR youth during both reward anticipation and outcome. However, after controlling for youth self-reports of depression, HR youth demonstrated lower striatal response than LR youth only during reward anticipation. No significant differences were found between HR and LR youth on subjective ratings of PA or depressive symptoms. Results are consistent with previous findings that reduced reward response is a marker of risk for depression, particularly during reward anticipation, even in the absence of (or accounting for) disrupted subjective mood. Further examinations of prospective associations between reward response and depression onset are needed.
DOI: 10.1016/j.dcn.2013.11.005
PubMed: 24369885
Affiliations:
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Olino</name><affiliation wicri:level="1"><nlm:affiliation>University of Pittsburgh, United States. Electronic address: thomas.olino@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh</wicri:regionArea></affiliation></author><author><name sortKey="Mcmakin, Dana L" sort="Mcmakin, Dana L" uniqKey="Mcmakin D" first="Dana L" last="Mcmakin">Dana L. Mcmakin</name><affiliation wicri:level="1"><nlm:affiliation>University of Pittsburgh, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh</wicri:regionArea></affiliation></author><author><name sortKey="Morgan, Judith K" sort="Morgan, Judith K" uniqKey="Morgan J" first="Judith K" last="Morgan">Judith K. Morgan</name><affiliation wicri:level="1"><nlm:affiliation>University of Pittsburgh, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh</wicri:regionArea></affiliation></author><author><name sortKey="Silk, Jennifer S" sort="Silk, Jennifer S" uniqKey="Silk J" first="Jennifer S" last="Silk">Jennifer S. 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Forbes</name><affiliation wicri:level="1"><nlm:affiliation>University of Pittsburgh, United States.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh</wicri:regionArea></affiliation></author></analytic><series><title level="j">Developmental cognitive neuroscience</title><idno type="eISSN">1878-9307</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Affect (physiology)</term><term>Anticipation, Psychological</term><term>Corpus Striatum (physiopathology)</term><term>Depressive Disorder (physiopathology)</term><term>Depressive Disorder (psychology)</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Reward</term><term>Risk</term><term>Self Report</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Affect (physiologie)</term><term>Anticipation psychologique</term><term>Autorapport</term><term>Corps strié (physiopathologie)</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Risque</term><term>Récompense</term><term>Trouble dépressif (physiopathologie)</term><term>Trouble dépressif (psychologie)</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Affect</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Affect</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Corps strié</term><term>Trouble dépressif</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Corpus Striatum</term><term>Depressive Disorder</term></keywords><keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Trouble dépressif</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Depressive Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Anticipation, Psychological</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Reward</term><term>Risk</term><term>Self Report</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Anticipation psychologique</term><term>Autorapport</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Risque</term><term>Récompense</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Offspring of depressed parents are at risk for depression and recent evidence suggests that reduced positive affect (PA) may be a marker of risk. We investigated whether self-reports of PA and fMRI-measured striatal response to reward, a neural correlate of PA, are reduced in adolescent youth at high familial risk for depression (HR) relative to youth at low familial risk for depression (LR). Functional magnetic resonance imaging assessments were conducted with 14 HR and 12 LR youth. All youth completed an ecological momentary assessment protocol to measure PA in natural settings and a self-report measure of depression symptomatology. Analyses found that HR youth demonstrated lower striatal response than LR youth during both reward anticipation and outcome. However, after controlling for youth self-reports of depression, HR youth demonstrated lower striatal response than LR youth only during reward anticipation. No significant differences were found between HR and LR youth on subjective ratings of PA or depressive symptoms. Results are consistent with previous findings that reduced reward response is a marker of risk for depression, particularly during reward anticipation, even in the absence of (or accounting for) disrupted subjective mood. Further examinations of prospective associations between reward response and depression onset are needed.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Olino, Thomas M" sort="Olino, Thomas M" uniqKey="Olino T" first="Thomas M" last="Olino">Thomas M. Olino</name></noRegion><name sortKey="Axelson, David A" sort="Axelson, David A" uniqKey="Axelson D" first="David A" last="Axelson">David A. Axelson</name><name sortKey="Birmaher, Boris" sort="Birmaher, Boris" uniqKey="Birmaher B" first="Boris" last="Birmaher">Boris Birmaher</name><name sortKey="Dahl, Ronald E" sort="Dahl, Ronald E" uniqKey="Dahl R" first="Ronald E" last="Dahl">Ronald E. Dahl</name><name sortKey="Forbes, Erika E" sort="Forbes, Erika E" uniqKey="Forbes E" first="Erika E" last="Forbes">Erika E. Forbes</name><name sortKey="Mcmakin, Dana L" sort="Mcmakin, Dana L" uniqKey="Mcmakin D" first="Dana L" last="Mcmakin">Dana L. Mcmakin</name><name sortKey="Morgan, Judith K" sort="Morgan, Judith K" uniqKey="Morgan J" first="Judith K" last="Morgan">Judith K. Morgan</name><name sortKey="Ryan, Neal D" sort="Ryan, Neal D" uniqKey="Ryan N" first="Neal D" last="Ryan">Neal D. Ryan</name><name sortKey="Silk, Jennifer S" sort="Silk, Jennifer S" uniqKey="Silk J" first="Jennifer S" last="Silk">Jennifer S. Silk</name><name sortKey="Williamson, Douglas E" sort="Williamson, Douglas E" uniqKey="Williamson D" first="Douglas E" last="Williamson">Douglas E. Williamson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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